Oestrogen also plays an important part in the development of the system’s secondary sexual characteristics. At puberty, as oestrogen production makes its first tentative faltering appearance, the typical features of the developing female gradually appear.
Oestrogen influences the development of the uterus and vagina, and external sexual characteristics. The vulval organs increase in size. The vagina becomes larger and develops its typical characteristics. Pubic, and later underarm hair develop. The breasts commence their development. Fat deposits of the body change and start to take on their typical feminine location—chest enlargement, more pronounced hips and bullocks, narrow waist.
The influence on the uterus is dramatic. Not only does this occur at puberty, when it is transformed from a juvenile organ into a fully developed adult one, but each month additional changes occur. Following ovulation, when there is a supercharge of oestrogen, the uterine internal lining, called the endometrium, becomes thick and prominent. Its blood supply increases dramatically. In short, it suddenly prepares to receive a fertilized egg. Would you believe it, but month in and month out, with unfailing regularity, in the average woman the uterus under hormonal stimulation prepares itself and waits for pregnancy. It never seems to tire, even though a pregnancy occurs in a very small number of cases. It offers an object lesson in patience and persistence.
Progesterone is the other female hormone. This also comes from the corpus luteum, which is fully productive about five days after ovulation has taken place.
Its main effect is on the uterus, but ii may also affect other organs to a lesser degree. It acts most forcibly on tissue (hat has been sensitized already by the influence of oestrogen. It aids and abets the oestrogen reaction, causing the endometrial lining of the uterus to become even thicker and more vascular (that is, the blood supply is greatly augmented). Once more, all this is in preparation for an expected pregnancy.
Incidentally, progesterone can have a few other effects, and these are often regarded with distaste by those concerned. Its presence in circulating blood can cause rapid overproduction of the sebaceous (fat-producing) glands in the skin. These are most plentiful in the face, scalp, chest and back regions. That is why many young women notice unattractive pimples, whiteheads and later blackheads appearing in the week preceding a normal menstrual period. The skin also tends to become more oily, particularly in those already burdened with greasy skin, his worth bearing this in mind, for it may be possible to schedule social engagements and other important functions at times when the progesterone levels are at their lowest ebb—and the risk of facial pimples likely to be less.
Another effect of progesterone is to raise the general body temperature by as much as 0.2 to 0.5° C. Although this is not really important in itself, it is often used when efforts are being made to pinpoint the date of ovulation. Carefully kept temperature graphs can indicate with considerable accuracy when ovulation has taken place, by the sudden increase in body basal temperature. Some women use the date system in trying to avoid pregnancy. Others use it if they are having difficulty in conceiving. For both reasons, it may be of practical importance, in any case, the system is available, for use in whichever way your doctor decides to use it in your own interest.
Progesterone also causes fluid retention, and in some women this can produce a series of symptoms that make life anything but enjoyable for many days each menstrual month. But we shall discuss this in more detail a little later.
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There are some cancers which are so likely to spread through the bloodstream that it is best to take it for granted that they already have when planning treatment. Combinations of chemotherapy with surgery and/or radiation have a higher chance of curing these types of cancer than any one treatment on its own. These cancers include acute leukaemias, rhabdomyosarcoma (cancer of muscle), Ewing’s sarcoma (a cancer of bone), Wilm’s tumour (a kidney cancer), and small cell anaplastic cancer of the lung. Chemotherapy is the mainstay of treatment for these types of cancer, because it travels through the blood and gets to nearly every part of the body. However, if local forms of treatment-surgery and radiation—are directed to the areas where cancer cells are most likely to escape being killed by the chemotherapy drugs, the cure rate is higher than if chemotherapy is used on its own.
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Cancer
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Radiation can be combined with other forms of treatment to produce cure rates which are greater than when any one treatment is used on its own. The radiation may be to the primary site or to likely or definite secondary sites. Ependymoma, and low grade astrocytoma are examples of  cancers which are more likely to be cured by a combination of surgery and radiation, both to the primary site, than by either [ surgery or radiation alone. These two examples are both brain  cancers which, because of their location, are difficult to remove completely. Radiation given after surgery increases the cure rate by killing any cells which have not been removed. As we will see in the next section, pre- or post-operative radiation to the primary site usually makes a difference only to the chance of local recurrence and not to the chance of complete cure. These cancers are I exceptions to this rule because they rarely spread outside of the central nervous system. Effective local treatment therefore has a good chance of curing them completely.  Some cancers which have spread can be cured by removing the primary cancer surgically and irradiating the secondary deposits. The main examples are seminoma (a type of testicular cancer) and dysgerminoma (a rare type of ovarian cancer). The primary cancer is removed mainly in order to make a definite and exact diagnosis. These types of cancer are so sensitive to radiation that even quite large secondary deposits can be destroyed completely К using safe doses of radiation. These cancers are also very sensitive to chemotherapy treatment. The chance of cure is greater with chemotherapy than with radiation if the disease is very extensive. However, chemotherapy has more side effects. If you have one of these types of cancer you will have to find out what figures apply in your particular case and exactly what each treatment would involve in order to make the best decision for you.
*275/40/1*
Cancer

Radiation can be combined with other forms of treatment to produce cure rates which are greater than when any one treatment is used on its own. The radiation may be to the primary site or to likely or definite secondary sites. Ependymoma, and low grade astrocytoma are examples of  cancers which are more likely to be cured by a combination of surgery and radiation, both to the primary site, than by either [ surgery or radiation alone. These two examples are both brain  cancers which, because of their location, are difficult to remove completely. Radiation given after surgery increases the cure rate by killing any cells which have not been removed. As we will see in the next section, pre- or post-operative radiation to the primary site usually makes a difference only to the chance of local recurrence and not to the chance of complete cure. These cancers are I exceptions to this rule because they rarely spread outside of the central nervous system. Effective local treatment therefore has a good chance of curing them completely.  Some cancers which have spread can be cured by removing the primary cancer surgically and irradiating the secondary deposits. The main examples are seminoma (a type of testicular cancer) and dysgerminoma (a rare type of ovarian cancer). The primary cancer is removed mainly in order to make a definite and exact diagnosis. These types of cancer are so sensitive to radiation that even quite large secondary deposits can be destroyed completely К using safe doses of radiation. These cancers are also very sensitive to chemotherapy treatment. The chance of cure is greater with chemotherapy than with radiation if the disease is very extensive. However, chemotherapy has more side effects. If you have one of these types of cancer you will have to find out what figures apply in your particular case and exactly what each treatment would involve in order to make the best decision for you.*275/40/1*
Cancer

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Although lymphoedema cannot be cured once it has developed, the arm-raising exercises can help to reduce the swelling and to prevent it getting worse. It may be controlled by a combination of regular, gentle exercise, massage (which you will have to be taught), general skin care and, when appropriate, by the wearing of an elastic compression sleeve. Although you can carry out most of the measures to control lymphoedema yourself, you must ask your doctor’s advice before starting any form of treatment.

*      Skin care. Germs can enter the body through dry, cracked skin, and you should therefore use a simple moisturizer after every bath. If your skin has become very rough, your doctor will be able to prescribe a special cream to treat it.

You should always protect the hand and arm on your affected side from injury and possible infection, for example by wearing gloves while you are gardening or using strong cleansing agents, and a thimble when sewing. If your hand or arm is cut or grazed, however small the injury, make sure it is thoroughly cleaned, treated with antiseptic, and covered with a clean dressing. If persistent inflammation or swelling follows an injury of this sort, ask your doctor’s advice as soon as possible.

Blood pressure measurement, blood tests and injections should be done on the other arm whenever possible.

*     Movement and exercise. Gravity tends to cause the lymph to pool, and its effect can be counteracted by raising the arm whenever possible. This can be done by resting your affected arm on a cushion – on the arm of a chair when sitting, and beside you when you are in bed – so that it is above the level of your heart.

Although too much exercise will cause the swelling to increase, gentle regular movement of the arm helps the lymphatic fluid to drain away. The exercises described above should be done gently at least once a day, while wearing a compression sleeve if you have one.

*     Massage. Massage of the affected arm and armpit, as well as of the lymph glands in the neck (and of the chest if fluid has started to accumulate here), will help lymphatic drainage away from the arm. A nurse or physiotherapist should be able to advise you about this, as specific lymph drainage massage must be done to ensure that it is effective. Massage clears the way ahead of the swelling so that fluid can drain from the swollen area. It should be gentle but firm, just enough to move the skin.

*     Compression sleeves. In some cases of lymphoedema, an elastic compression sleeve may be worn which prevents fluid building up in the arm and provides support to the muscles. These sleeves can be obtained from a hospital appliance officer, to whom you must be referred by your consultant or breast care nurse.

Compression sleeves should be put on in the morning when the swelling is least, and can be removed at night. Moist skin makes them more difficult to apply, and it is therefore best not to have a bath immediately before fitting your sleeve. Once the sleeve is on, it should be smooth and creaseless. It should never be rolled back as it will act as a tourniquet. The elastic gradually loses its strength and the sleeve will need to be replaced every 3 to 4 months.

It is important that you wear your elastic sleeve in hot weather, even though it may be uncomfortable, as this is a time when your arm is likely to swell.

*     Compression pumps. The use of a compression pump is not always suitable in every case; your doctor will be able to advise you about this. The pump is attached by a small tube to an inflatable cuff, and is powered from the mains electricity. Air is pumped in to inflate the cuff and is then gradually sucked out to deflate it again. The effect is a gentle squeezing of the arm which assists the drainage of lymph away from it. Compression pumps are normally used at regular intervals throughout the day to help reduce swelling.

Your pump should not be used if you have an infection in your arm, swelling in your chest, or if it causes pain.

If you are attending a lymphoedema clinic, your progress will be regularly monitored and you will be given advice about all the measures you can take to help control the condition.

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